Primary afferent nerves bring pain signals through the dorsal root ganglion and synapse in the cord at (or one or two level above or below) the level of entry on dorsal horn laminar nucleus, probably lamina II and IV (the marginal nuclei). The secondary fibers cross the cord and ascend surrounded by the lateral spinothalamic tracts (part of the anterolateral system) of the spinal cord and synapse principally on the ventral postereriolateral (VPL) thalamic nuclei. Tertiary fibers ascending to the cortex are call thalamocortical fibers. They project onto the primary somatosensory cortex, Brodmann's areas 3,1 and 2, which then project to minor association cortical regions.
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